The Nashville Business Incubation Center has been operational since 1986 and continues as one of the most successful small business incubation centers in the United States. Businesses that grow through the incubation center become successful, and remain sustainable. NBIC offers onsite and virtual assistance, such as mentoring, one-on-one business counseling and peer support, as well as programs and classes to keep these established small businesses informed on business trends and best practices to help businesses build a stronger foundation for future successes.

NBIC provides office space for businesses to grow and has space for 26 small businesses of varying sizes. NBIC is the only small-business incubation center in Middle Tennessee, with other incubation centers located in Chattanooga, Memphis and Oak Ridge. NBIC is governed by the nonprofit, Growth Enterprises Nashville Incorporated.

In 1995 the NBIC underwent a $1.4 million expansion with a grant from the U.S. Department of Commerce. With this expansion, the capacity of the NBIC increased from supporting and housing 10 small businesses to 22.  Since that time, NBIC has been able to grow to host 26 small businesses.